Founded in 1999, the Colorectal Cancer Alliance is the leading nonprofit organization dedicated to ending colorectal cancer within our lifetime. It honors the memory of Christine Sapienza and supports affected families through investments in research—totaling nearly $10 million, including nearly $3 million in early-stage grants to innovative researchers.
Project Cure CRC by the Colorectal Cancer Alliance seeks proposals for high-impact preclinical and clinical translational research in colorectal cancer diagnosis, treatment, or survivorship. Focused on shifting research toward a curative science, the program encourages High-Risk/High-Reward projects that expedite new therapies and technologies. It supports collaborations and public-private partnerships, offering awards across various categories to both academic and industry researchers. The program aims to fund tens of millions towards research and infrastructure needed to advance colorectal cancer care, seeking proposals in areas like immunotherapy, liquid biopsies, enhancing clinical trials, developing recurrence prevention therapies, leveraging AI for precision medicine, targeting cell signaling pathways, and creating supportive infrastructures for patient data. Specific strategic awards support Phase II and III clinical trials by small biotech or pharmaceutical companies, with funding up to $5,000,000 per year.