The mission of the Hereditary Disease Foundation is to fund the most promising, innovative, and paradigm-changing research aimed at curing Huntington’s disease. This genetic brain disorder causes irreversible declines in mood, memory, and movement control, with no current cure or treatment available. By focusing on this single-gene disorder, the foundation hopes to unlock potential cures for other brain disorders such as Parkinson’s, Alzheimer’s, and Lou Gehrig’s (ALS) diseases.
The HDF Transformative Research Award program is designed to support transformational collaborative projects that offer new insights into disease mechanisms or introduce tools and technologies not previously applied to Huntington's disease research, with the ultimate goal of advancing therapeutics. The program encourages projects that present innovative approaches to understanding new pathogenic mechanisms and treatment modalities in Huntington’s disease. This includes exploration into somatic repeat instability, predictive cellular, biochemical, or molecular insights in Huntington’s disease systems, and the application of unexplored therapeutics, including biomarkers. Projects should aim to discover disease-modifying targets and incorporate novel tools or technologies, justifying how their results could lead to therapies. The initiative seeks to stimulate revolutionary advances in fundamental new disease mechanisms or novel therapeutic approaches. Emphasis will be placed on exceptional novelty and a credible research path toward impacting Huntington’s disease research or therapies. Incremental advances previously described in literature are not within scope. This funding opportunity focuses exclusively on developing and testing new ideas, with proposers expected to establish their metrics and milestones for success. Funding can range from $300,000-500,000 annually for up to two years, with necessary justification.
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