NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required)

    From US Department of Health & Human Services: National Institutes of Health (NIH)

    The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the nation’s medical research agency — making important discoveries that improve health and save lives.

    Type of Support

    Overview

    This Notice of Funding Opportunity (NOFO) supports mid-phase clinical trials of natural products including botanicals, dietary supplements, and probiotics with a strong scientific premise for further clinical testing. It focuses on nutritional regimens standardizing specific naturally occurring nutritional compounds with preliminary evidence of effectiveness. The NOFO aims to determine optimal doses/formulations for future efficacy trials or identify patient phenotypes for responsive/non-responsive outcomes. Applicants must provide preliminary data on bioavailability and measurable impact on target engagement. Trials must be hypothesis-based and milestone-driven, aligning with the research priorities of the funding organization.

    Eligibility

    Organization's Location
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    Program Location
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    Organization Type

    Submission

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